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- Title
Synthesis and Anticoagulant Bioactivity of Heterocyclic Derivatives of Resveratrol.
- Authors
Yang, H. J.; Ren, Y. J.; Du, C.; Jin, L.; Li, R.; Xie, N.
- Abstract
Twenty-five resveratrol derivatives were synthesized, among which eight compounds have not yet been reported. The target compounds were evaluated for thrombin inhibitory activity in vitro (IC50). The results showed that four compounds displayed a better thrombin inhibitory activity with IC50 values from 10.43 to 18.31 μM, better than resveratrol (25.87 μM). The R3 position of resveratrol was modified by heterocyclic rings containing oxygen and sulfur, which could increase the anticoagulant activity of resveratrol.
- Subjects
ANTICOAGULANTS; RESVERATROL; HETEROCYCLIC compounds synthesis; BIOACTIVE compounds; CHEMICAL derivatives; ANTITHROMBINS
- Publication
Chemistry of Natural Compounds, 2018, Vol 54, Issue 5, p864
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-018-2500-2