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- Title
Alpha-tocopherol supplementation decreases electronegative low-density lipoprotein concentration [LDL(-)] in haemodialysis patients.
- Authors
Denise Mafra; Felipe Rizzetto Santos; Julie Calixto Lobo; Daniela de Mattos Grosso; André Luis Barreira; Luis Guillermo Coca Velarde; Dulcinéia Saes Parra Abdalla; Maurilo Leite
- Abstract
Background. Oxidative stress is a significant contributor to cardiovascular diseases (CVD) in haemodialysis (HD) patients, predisposing to the generation of oxidized low-density lipoprotein (oxLDL) or electronegatively charged LDL subfraction. Antioxidant therapy such as α-tocopherol acts as a scavenger of lipid peroxyl radicals attenuating the oxidative stress, which decreases the formation of oxLDL. The present study was designed to investigate the influence of the α-tocopherol supplementation on the concentration of electronegative low-density lipoprotein [LDL(−)], a minimally oxidized LDL, which we have previously described to be high in HD patients. Methods. Blood samples were collected before and after 120 days of supplementation by α-tocopherol (400 UI/day) in 19 stable HD patients (50 ± 7.8 years; 9 males). The concentrations of LDL(−) in blood plasma [using an anti-LDL− human monoclonal antibody (mAb)] and the anti-LDL(−) IgG auto-antibodies were determined by ELISA. Calculation of body mass index (BMI) and measurements of waist circumference (WC), triceps skin folds (TSF) and arm muscle area (AMA) were performed. Results. The plasma α-tocopherol levels increased from 7.9 μM (0.32–18.4) to 14.2 μM (1.22–23.8) after the supplementation (P = 0.02). The mean concentration of LDL(−) was reduced from 570.9 μg/mL (225.6–1241.0) to 169.1 μg/mL (63.6–621.1) (P P P Conclusion. The oral administration of α-tocopherol in HD patients resulted in a significant decrease in the LDL(−), total cholesterol and LDL-C levels. This effect may favour a reduction in cardiovascular risk in these patients, but a larger study is required to confirm an effect in this clinical setting.
- Subjects
VITAMIN E content of food; DIETARY supplements; ELECTRONEGATIVITY; LOW density lipoproteins; HEMODIALYSIS patients; OXIDATIVE stress; CARDIOVASCULAR diseases; BLOOD testing
- Publication
Nephrology Dialysis Transplantation, 2009, Vol 24, Issue 5, p1587
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfn760