We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Comparative Pathology of Intranasal, Intratracheal, or Small Particle Aerosol Exposure of SARS-CoV-2 (COVID-19) Virus in Five Animal Models.
- Authors
Raymond, Jo Lynne W.; Cline, Curtis R.; Lee, Eric D.; Kim, Robert K.; Moreau, Alicia M.; Wang, Guanghua; Zeng, Xiankun; Williams, Janice A.; Facemire, Paul R.
- Abstract
A novel coronavirus, SARS-CoV-2, first identified in Wuhan, China, in late 2019, caused a global pandemic resulting in significant morbidity and mortality in humans worldwide. Disease presentations in humans range from asymptomatic virus carriers to fatal systemic disease. A historic effort is underway to develop therapeutics and vaccines to slow or stop virus spread and treat those infected with coronavirus disease (COVID-19). Animal models play vital roles in understanding the pathogenesis of SARS-CoV-2 and evaluating therapeutics and vaccines. We compare the pathologic findings, including macroscopic, microscopic, and molecular findings, in three nonhuman primate species (cynomolgus macaques, rhesus macaques, and African green monkeys), ferrets, guinea pigs, hamsters, and mice following experimental exposure to SARS-CoV-2 by the intranasal, intratracheal or small particle aerosol routes to the disease as it occurs in humans who died during the current pandemic.
- Subjects
WUHAN (China); MICROBIOLOGICAL aerosols; HAMSTERS; COVID-19; CERCOPITHECUS aethiops; ANIMAL models in research; GUINEA pigs; SARS-CoV-2
- Publication
Medical Journal, US Army Medical Center of Excellence (MEDCoE), 2023, p116
- ISSN
2694-3581
- Publication type
Article