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- Title
Brucellosis in pregnancy and its response to the changing immunoglobulin A: A prospective controlled study.
- Authors
Kırmızı, Demet Aydoğan; Başer, Emre; Şölen, Emine Yeşilyurt; Kara, Mustafa; Çaltekin, Melike Demir; Yılmaz, Neziha; Onat, Taylan; Yalvaç, Ethem Serdar
- Abstract
Objective: This study aimed to define the rare Brucella infection in pregnancy and its effects on immunoglobulins (Ig). Materials and Methods: This prospective study has conducted Brucella screening using the Rose Bengal test on pregnant and non-pregnant outpatients who did not show any specific Brucella symptoms. The immunoglobulin levels were measured using the enzyme-linked immunosorbent assay. The study group consisted of pregnant women who were at 20 weeks or below gestation and applied to our hospital outpatient clinic for routine check-ups. The control group consisted of healthy patients who applied for routine controls. Results: This study included a total of 584 participants, 293 of whom were controls and 291 were the study (pregnant) participants. The study revealed a 1.5% incidence of Brucella during pregnancy. In acute and chronic Brucella infection, lower levels of IgA response were observed in pregnant cases compared to the control group. Conclusion: Brucella infection is a disease that can cause fetal problems, especially in endemic areas. The role of the altered IgA response in pathologies that are associated with Brucella infection stands out as a new target for disease pathophysiology.
- Subjects
IMMUNOGLOBULIN A; BRUCELLOSIS; PATHOLOGICAL physiology; FETAL abnormalities; ENZYME-linked immunosorbent assay
- Publication
Turkish Journal of Obstetrics & Gynecology, 2022, Vol 19, Issue 1, p1
- ISSN
2149-9322
- Publication type
Article
- DOI
10.4274/tjod.galenos.2022.37530