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- Title
基于“肝-肠轴”研究蒸脐疗法对肝硬化合并肠道 菌群失调的临床疗效<sup>Δ</sup>.
- Authors
蒋南飞; 葛来安; 贺柯庆; 谢明君; 黄雪云; 张静
- Abstract
OBJECTIVE: To probe into the effects of steam therapy on liver cirrhosis and gut microbiota dysbiosis based on “liver-gut axis” and its clinical efficacy. METHODS: A total of 80 patients with liver cirrhosis and gut microbiota dysbiosis admitted into the hospital from Mar. 2021 to Sept. 2022 were extracted to be divided into the observation group ( n = 40) and control group ( n = 40) by single blind and random method. The treatment group received steam therapy, while the control group was given traditional supportive treatment. The treatment period was 12 weeks. Quantitative detection of gut microbiota was conducted before treatment, after treatment of 4, 8 and 12 weeks. Clinical indicators and clinical staging were recorded and SPSS statistical analysis was performed. RESULTS: The total effective rate of improvement of cirrhosis symptom in the observation group was 75. 0% (29 / 40), significantly higher than 50. 0% ( 20 / 40) in the control group; the total effective rate of improvement of intestinal flora was 80. 0% (32 / 40), significantly higher than 52. 5% ( 21 / 40) of the control group, the difference between two groups was statistically significant (P<0. 05). After treatment, the levels of ALT, AST and TBIL in the observation group were significantly lower than those before treatment, and the levels of ALB were significantly higher than those before treatment, with statistically significant differences (P was 0. 011, 0. 002, 0. 005 and 0. 001, respectively); there was no statistically significant difference in the levels of ALT,AST,TBIL and ALB before and after treatment in control group (P>0. 05). After treatment, the abundance of Bifidobacteria, Firmicutes/ Bacteroidetes in the observation group was significantly higher than those before treatment, while the abundance of Bifidobacteria in the control group after treatment was higher than those before treatment, with statistically significant differences (P<0. 05). After treatment, the number of Escherichia coli and alcaligenaceae bacteria in the observation group decreased significantly compared with before treatment, while the number of Bifidobacterium, Firmicutes/ Bacteroidetes bacteria increased significantly compared with before treatment, with statistically significant differences (P<0. 05 ). There was no significant difference in the incidence of nausea, vomiting, headache and vertigo between two groups (P>0. 05 ).
- Subjects
CIRRHOSIS of the liver; GUT microbiome; DYSBIOSIS; BACTEROIDETES
- Publication
Evaluation & Analysis of Drug-Use in Hospitals of China, 2023, Vol 23, Issue 9, p1052
- ISSN
1672-2124
- Publication type
Article
- DOI
10.14009/j.issn.1672-2124.2023.09.004