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- Title
Physiological functions of docosapentaenoic acid (22 : 5n-3).
- Authors
OSHIDA Kyoichi
- Abstract
Nutrition in Omega-3 fatty acids are docosahexaenoic acid (DHA, 22 : 6n-3) and eicosapentaenoic acid (EPA, 20 : 5n-3), which rich in seafood was studied in epidemiological and clinical areas. This study summarizes the nutritional role of docosapentaenoic acid (DPA, 22 : 5n-3), a new Omega-3 fatty acid which has received considerable attention recently. DPA has been known as a component of seal oil, which is consumed by the Inuit people of Greenland daily. A low prevalence of cardiovascular disease has been found in Greenland. In vitro studies showed that DPA is more effective than EPA or DHA in inhibiting platelet aggregation. There is a negative correlation between blood DPA levels and perinatal depression and cognitive function, indicating its efficacy as a nutritional prevention and treatment for mental health. The percentage of DPA in breast milk is higher than EPA and is the second most abundant Omega-3 fatty acid after DHA. It has been suggested that 14-hydroxy-DPA (14-HDPA), which is in breast milk, produced in metabolized DPA, can prevent allergies in infants. DHA is synthesized from DPA in human body and is also converted back to EPA. Since the aforementioned metabolites derived from DPA have strong anti-inflammatory and cytoprotective effects, it is recommended that direct intake of DPA in the form of DPA from food is necessary to maintain healthy. Further research of its physiological effects will be the focus in the future.
- Subjects
GREENLAND; DOCOSAHEXAENOIC acid; EICOSAPENTAENOIC acid; OMEGA-3 fatty acids; MENTAL health services; BLOOD platelet aggregation; BREAST milk; ACIDS; DISEASE prevalence
- Publication
China Food Additives, 2023, Vol 34, Issue 1, p320
- ISSN
1006-2513
- Publication type
Article
- DOI
10.19804/j.issn1006-2513.2023.01.039