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- Title
Evaluation of the Treatment of Stenotrophomonas maltophilia in Tracheostomy-Dependent Pediatric Patients.
- Authors
Tillman, Emma M.; Firmani, Sarah E.; Ackerman, Veda L.; Slaven, James E.; Cristea, A. Ioana
- Abstract
OBJECTIVE Tracheostomy-dependent pediatric patients will often have respiratory cultures positive for Stenotrophomonas maltophilia (multidrug-resistant Gram-negative rod). There are limited data available to guide treatment in this population. The objective of this single-center, retrospective study was to evaluate if antibiotic treatment of S maltophilia improved clinical outcomes in tracheostomy-dependent pediatric patients. METHODS We included tracheostomy-dependent pediatric patients who had a respiratory culture positive for S maltophilia. Patients were divided into 2 groups: 1) treatment and 2) no treatment. RESULTS Forty patients with 55 encounters were included in this study. S maltophilia was treated with sulfamethoxazole-trimethoprim in 20 encounters (19 patients) and no antimicrobial treatment was given in 35 encounters (30 patients). The time to return to stable respiratory status was 5 days (0-10) (median [range]) in the treated group and 4 days (0-19) in the untreated group (p = 0.52). There was no statistically significant difference in time to baseline respiratory status between patients treated and those not treated for S maltophilia. There was no difference in hospital length of stay between patients who were or not treated. CONCLUSIONS Based on these results, these data would suggest that there might not be a benefit to treating cultures positive for S maltophilia in tracheostomy-dependent pediatric patients.
- Subjects
TRACHEOTOMY; STENOTROPHOMONAS maltophilia; PROTEOBACTERIA; BACTERIAL diseases in children; GRAM-negative bacterial diseases
- Publication
Journal of Pediatric Pharmacology & Therapeutics, 2019, Vol 24, Issue 6, p510
- ISSN
1551-6776
- Publication type
Article
- DOI
10.5863/1551-6776-24.6.510