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- Title
Plasma ceramides relate to mild cognitive impairment in middle‐aged men: The Maastricht Study.
- Authors
van Kruining, Daan; Losen, Mario; Crivelli, Simone M.; de Jong, Joost J. A.; Jansen, Jacobus F. A.; Backes, Walter H.; Monereo‐Sánchez, Jennifer; van Boxtel, Martin P. J.; Köhler, Sebastian; Linden, David E. J.; Schram, Miranda T.; Mielke, Michelle M.; Martinez‐Martinez, Pilar
- Abstract
Introduction: There is an urgent need for biomarkers identifying individuals at risk of early‐stage cognitive impairment. Using cross‐sectional data from The Maastricht Study, this study included 197 individuals with mild cognitive impairment (MCI) and 200 cognitively unimpaired individuals aged 40 to 75, matched by age, sex, and educational level. Methods: We assessed the association of plasma sphingolipid and ceramide transfer protein (CERT) levels with MCI and adjusted for potentially confounding risk factors. Furthermore, the relationship of plasma sphingolipids and CERTs with magnetic resonance imaging brain volumes was assessed and age‐ and sex‐stratified analyses were performed. Results: Associations of plasma ceramide species C18:0 and C24:1 and combined plasma ceramide chain lengths (ceramide risk score) with MCI were moderated by sex, but not by age, and higher levels were associated with MCI in men. No associations were found among women. In addition, higher levels of ceramide C20:0, C22:0, and C24:1, but not the ceramide risk score, were associated with larger volume of the hippocampus after controlling for covariates, independent of MCI. Although higher plasma ceramide C18:0 was related to higher plasma CERT levels, no association of CERT levels was found with MCI or brain volumes. Discussion: Our results warrant further analysis of plasma ceramides as potential markers for MCI in middle‐aged men. In contrast to previous studies, no associations of plasma sphingolipids with MCI or brain volumes were found in women, independent of age. These results highlight the importance of accounting for sex‐ and age‐related factors when examining sphingolipid and CERT metabolism related to cognitive function.
- Subjects
COMPUTER Emergency Response Team; MILD cognitive impairment; MIDDLE-aged men; CERAMIDES; DISEASE risk factors; MAGNETIC resonance imaging
- Publication
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023, Vol 15, Issue 3, p1
- ISSN
2352-8729
- Publication type
Article
- DOI
10.1002/dad2.12459