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- Title
Validating the Health Benefits of Coffee Berry Pulp Extracts in Mice with High-Fat Diet-Induced Obesity and Diabetes.
- Authors
Bashir, Khawaja Muhammad Imran; Kim, Joo Wan; Park, Hye-Rim; Lee, Jae-Kyoung; Choi, Beom-Rak; Choi, Jae-Suk; Ku, Sae-Kwang
- Abstract
The effects of coffee (Coffea arabica L.) berry pulp extracts (CBP extracts) on the improvement of diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD) were evaluated using various in vitro antioxidant activity assays and through a high-fat diet-induced mild diabetic obese mouse model. After an 84-day oral administration of CBP extracts (400–100 mg/kg), bioactivities were evaluated. The in vitro analysis showed the highest DPPH● scavenging activity of 73.10 ± 4.27%, ABTS● scavenging activity of 41.18 ± 1.14%, and SOD activity of 56.24 ± 2.81%, at a CBP extract concentration of 1000 µg/mL. The in vivo analysis of the CBP extracts showed favorable and dose-dependent anti-obesity, anti-diabetic, NAFLD, nephropathy, and hyperlipidemia refinement effects through hepatic glucose enzyme activity, 5′-AMP-activated protein kinase (AMPK) up-regulation, antioxidant activity, lipid metabolism-related gene expression, and pancreatic lipid digestion enzyme modulatory activities. This study shows that an appropriate oral dosage of CBP extracts could function as a potent herbal formulation for a refinement agent or medicinal food ingredient to control type 2 diabetes and related complications.
- Subjects
NON-alcoholic fatty liver disease; ORAL drug administration; TYPE 2 diabetes; FAT; DIABETES complications; COFFEE; PANCREATIC enzymes
- Publication
Antioxidants, 2024, Vol 13, Issue 1, p10
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox13010010