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- Title
Anti-Inflammatory, Neurotrophic, and Cytotoxic Oxylipins Isolated from Chaenomeles sinensis Twigs.
- Authors
Lee, Da Yeong; Park, Kyoung Jin; Subedi, Lalita; Lee, Gyu Sung; Lee, Ji-Hyeok; Lee, Won-Min; Choi, Sang Un; Hong, Seong-Min; Kim, Sun Yeou; Kim, Chung Sub
- Abstract
Oxylipins are important biological molecules with diverse roles in human and plants such as pro-/anti-inflammatory, antimicrobial, and regulatory activity. Although there is an increasing number of plant-derived oxylipins, most of their physiological roles in humans remain unclear. Here, we describe the isolation, identification, and biological activities of four new oxylipins, chaenomesters A–D (1–4), along with a known compound (5), obtained from Chaenomeles sinensis twigs. Their chemical structures were determined by spectroscopic (i.e., NMR) and spectrometric (i.e., HRMS) data analysis including 1H NMR-based empirical rules and homonuclear-decoupled 1H NMR experiments. Chaenomester D (4), an omega-3 oxylipin, showed a potent inhibitory effect on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells (NO production, 8.46 ± 0.68 μM), neurotrophic activity in C6 cells through the induction of the secretion of nerve growth factor (NGF, 157.7 ± 2.4%), and cytotoxicity in A549 human cancer cell lines (IC50 = 27.4 μM).
- Subjects
OXYLIPINS; NERVE growth factor; FISH oils; TWIGS; BIOMOLECULES; NEUROSECRETION; CANCER cells
- Publication
Antioxidants, 2023, Vol 12, Issue 2, p284
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox12020284