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- Title
Venous aneurysm complicating arteriovenous fistula access and matrix metalloproteinases.
- Authors
Serra, Raffaele; Butrico, Lucia; Grande, Raffaele; Placida, Girolamo Domenico; Rubino, Paolo; Settimio, Ugo Francesco; Quarto, Gennaro; Amato, Maurizio; Furino, Ermenegildo; Compagna, Rita; Amato, Bruno; Gallelli, Luca; de Franciscis, Stefano
- Abstract
Introduction: An arteriovenous fistula (AVF) for placed for hemodialysis may be burdened by one particular complication—the formation of a venous aneurysm. It has been shown that matrix metalloproteinases (MMPs) and neutrophil gelatinase-associated lipocalin (NGAL) could represent markers of disease in both venous and arterial vessels. Materials and methods: This case study reports a rare case of enormous venous aneurysm-correlated MMP and NGAL levels in a woman with an AVF. Results: Significantly higher levels of plasma MMP-1, MMP-8, MMP-9, and NGAL were detected in this patient during aneurysmal evaluation before the surgery; these levels significantly decreased 1, 3 and 6 months after surgery. Conclusion: MMP and NGAL levels could represent a marker of aneurysmal disease, and their plasma evaluation could help physicians to stratify the risk of complications in patients with an AVF.
- Publication
Open Medicine, 2015, Vol 10, Issue 1, p519
- ISSN
2391-5463
- Publication type
Article
- DOI
10.1515/med-2015-0088