We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Disturbed oxidant/antioxidant balance in aqueous humour of patients with exfoliation syndrome.
- Authors
Beyazyıldız, Emrullah; Çankaya, Ali; Beyazyıldız, Özlem; Ergan, Esra; Çelik, Hüseyin; Yılmazbaş, Pelin; Öztürk, Faruk
- Abstract
Purpose: To establish the total oxidant status (TOS), total antioxidant capacity (TAC) and oxidative stress index (OSI) of the aqueous humour in patients presenting exfoliation syndrome (EXS) without glaucoma. Methods: The TOS, TAC and OSI of the aqueous humour of patients with EXS (group 1, n = 17) and patients without EXS (group 2, n = 25) who underwent cataract surgery were evaluated. Samples were measured spectrophotometrically using a colourimetric method. The Mann-Whitney U, independent-samples t tests, Pearson correlation and analysis of covariance tests were used in the statistical analyses. Results: The mean TOS in group 1 and 2 patients was 57.6 ± 32.4 and 30.4 ± 22.6 mmol/L, respectively, which is a statistically significant difference ( p = 0.001). The mean TAC level in group 1 and 2 patients was 2.3 ± 0.7 and 2.5 ± 0.7 mmol/L, respectively, and although TAC was decreased in group 1 relative to group 2, the difference was not statistically significant ( p = 0.55). The mean OSI in group 1 and 2 patients was 27.4 ± 17.1 and 12.5 ± 8.3 mmol/L, respectively, with the mean OSI level statistically higher in group 1 ( p = 0.03). Conclusion: Our findings provide evidence that the aqueous humour of EXS patients is characterised by increased oxidative stress and a disturbed oxidant/antioxidant balance. The increased oxidative stress and decreased levels of antioxidants in ocular fluids of EXS patients may play a significant role in the pathogenesis and complications of EXS.
- Subjects
ANTIOXIDANTS; AQUEOUS humor; EXFOLIATION syndrome; OXIDATIVE stress; GLAUCOMA; SPECTROPHOTOMETRY; PATIENTS
- Publication
Japanese Journal of Ophthalmology, 2014, Vol 58, Issue 4, p353
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-014-0325-5