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- Title
Prospective Cohort Study Identifies Medical Predictors of Treatment-Related Oral Toxicities in Oral and Oropharyngeal Cancer Patients.
- Authors
Rodrigues-Oliveira, Leticia; Rivera, César; López-Cortés, Xaviera A.; Mak, Milena Perez; Mores, Ana Leticia; Migliorati, Cesar Augusto; Querido de Oliveira, Maria Cecília; Palmier, Natalia Rangel; Gueiros, Luiz Alcino; Vargas, Pablo Agustin; Brandão, Thaís Bianca; Santos-Silva, Alan Roger; Prado-Ribeiro, Ana Carolina
- Abstract
The dental treatment of patients with oral cavity and oropharyngeal squamous cell carcinoma (OOPSCC) may be challenging for dentists. This study aimed to characterize systemic changes in patients with OOPSCC undergoing dental treatment prior to cancer therapy, with a specific focus on laboratory assessments. The primary objectives included identifying potential adverse events, such as infections or bleeding, resulting from dental procedures. Additionally, the study aimed to correlate baseline patient characteristics with treatment-related toxicities. This was a prospective cohort study that included 110 OOPSCC patients referred to the Dental Oncology Service at São Paulo State Cancer Institute, Brazil, between November/2019 and December/2020. Comorbidities, sociodemographic data, medication in use, cancer treatment-related toxicities, and altered laboratory tests results were correlated. The most common comorbidities and altered laboratory results were hypertension, dyslipidemia, diabetes, as well as elevated levels of C-reactive protein, hemoglobin, and hematocrit. Toxicities exhibited a progressive pattern over time, encompassing oral mucositis (OM), xerostomia, dysphagia, dysgeusia, trismus, and radiodermatitis. No correlation between comorbidities and cancer treatment-related toxicities, a positive correlation between medications in use and OM, and a negative correlation between medications and dysgeusia were found. OM was associated with altered thyroxine (T4) and free thyroxine (FT4), calcium, urea, creatinine, alkaline phosphatase, and syphilis. Family income and housing were OM predictors. Altered T4/FT4/urea/calcium/alkaline phosphatase/creatinine/syphilis may be useful clinical predictors of OM. Despite the elevated prevalence of comorbidities and abnormal laboratory findings, dental treatment prior to cancer treatment yielded no adverse events.
- Subjects
SAO Paulo (Brazil : State); BRAZIL; OROPHARYNGEAL cancer; ORAL cancer; CANCER patients; COHORT analysis; LONGITUDINAL method
- Publication
Dentistry (2304-6767), 2024, Vol 12, Issue 4, p89
- ISSN
2304-6767
- Publication type
Article
- DOI
10.3390/dj12040089