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- Title
Genomic variants at 20p11 associated with body fat mass in the European population.
- Authors
Pei, Yu‐Fang; Ren, Hai‐Gang; Liu, Lu; Li, Xiao; Fang, Chen; Huang, Yun; Hu, Wen‐Zhu; Kong, Wei‐Wen; Feng, An‐Ping; You, Xin‐Yi; Zhao, Wen; Shen, Hui; Tian, Qing; Zhang, Yong‐Hong; Deng, Hong‐Wen; Zhang, Lei; Pei, Yu-Fang; Ren, Hai-Gang; Hu, Wen-Zhu; Kong, Wei-Wen
- Abstract
<bold>Objective: </bold>Body fat mass (BFM) is more homogeneous and accurate than body total mass in measuring obesity but has rarely been studied. Aiming to uncover the genetic basis of fat-induced obesity, a genome-wide association meta-analysis of BFM, after adjustment by body lean mass, was performed in the European population.<bold>Methods: </bold>Three samples of European ancestry were included in the meta-analysis: the Framingham Heart Study (N = 6,004), the Kansas City osteoporosis study (N = 2,207), and the Omaha osteoporosis study (N = 968).<bold>Results: </bold>At the genome-wide significance level (α = 5.0×10-8 ), a cluster of 10 single-nucleotide polymorphisms (SNPs) at chromosomal region 20p11 that were associated with BFM (lead SNP rs2069126, P = 1.82×10-9 , closest gene SLC24A3) was identified in 9,179 subjects. One of the top SNPs, rs6046308 (P = 3.74×10-8 ), was found to be nominally significant for body fat percentage in another independent study (P = 0.03, N = 75,888) and was reported to transregulate the expression of the MPZ gene at 1q23.3 (unadjusted P = 9.78×10-6 , N = 1,490). Differential gene expression analysis demonstrated that SLC24A3 and CFAP61 at the identified locus were differentially expressed in tissues of people with versus without obesity (P = 3.40×10-5 and 8.72×10-4 , N = 126 and 70), implying their potential role in fat development.<bold>Conclusions: </bold>These results may provide new insights into the biological mechanism that underlies fat-induced obesity pathology.
- Subjects
FAT; BODY mass index; OBESITY; METABOLIC disorders; NUTRITION disorders; TYPE 2 diabetes; METABOLIC syndrome; ADIPOSE tissues; CHROMOSOMES; COMPARATIVE studies; GENETIC polymorphisms; RESEARCH methodology; MEDICAL cooperation; META-analysis; RESEARCH; RESEARCH funding; WHITE people; GENOMICS; EVALUATION research; SEQUENCE analysis
- Publication
Obesity (19307381), 2017, Vol 25, Issue 4, p757
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.21775