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- Title
GKS for the multiple brain tumors and AVMs.
- Authors
Mooseong Kim; Daehyun Sea; Won hee Lee
- Abstract
Objective: The effectiveness of GammaKnife radiosurgery as primary treatment for small to medium sized brain tumors, AVM has been reported. But, the treatment of the multiple brain tumors and AVM, several times surgery is needed and we assessed the Gamma Knife Radiosurgery for multiple brain lesions . Methods: Between October, 1994 and December 2014, 12 patients with multiple brain lesions were treated with Gamma Knife radiosurgery (GKS). 2 patients (16.7 %) had AVM, 2 patients (16.7 %) had germinomas, 6 patients (50..0%) had multiple meningiomas, 1 patients (8.4 %) had meningiomas and pituiatry adenoma, 1 patient (8.4 %) had meningioma and schwannoma. The mean radiosurgical tumor volume was 5.6 ml (range 0.5-36 ml). The mean dose delivered to the lesion center was 25.2 Gy (range 20-45) and to the margin was 14.1 Gy (10-22.5 Gy). Results: All patients underwent serial MRI scanning with a mean duration of imaging follow-up 45 months (range 5-110). Among the 2 AVM patients, two lesions were treated with GammaKnife Surgery. In 1 patient the AVM was disappeared, 1 patient showed partial obliteration and retreated with Gamma Knife Surgery after 84 months. Pre Gamma Knife surgery, 2 germinoma patients (44%) underwent biopsies. And they received treated with GammaKnife surgery and booster radiotherapy. Imaging in 2 patients (32.3 %) demonstrated complete response during mean 56.5 months (range 55-58 months). Among the multiple meningioma patients, all 6 patients the tumor were stationary. Of 1 patient with meningioma and pituiatry tumor, initial she treated meningioma with GammaKnife surgery, but 4 years later, pituitary tumor was developed and retreated with GammaKnife surgery, which showed partial response through follow-up MRI image. In 1 pituiatry tumor and low cranial nerve schwannoma patient, partial response after GammaKnife surgery. Conclusion: Gamma-Knife radiosurgery is safe and effective treatment of multiple brain tumors and AVMs. Especially in cases of multiple AVM or meningioma, pituiatry tumor, schwannomas, silmultaneously treatment showed better results than the surgery. GK provides one time treated an advantage for all multiple brain tumors or AVMs.
- Publication
Stereotactic & Functional Neurosurgery, 2017, Vol 95, p392
- ISSN
1011-6125
- Publication type
Article