We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Intracranial bleeding in acute promyelocytic leukemia treated with arsenic trioxide based regimens is associated with induction mortality but not with relapse.
- Authors
Kulkarni, Uday Prakash; Selvarajan, Sushil; Fouzia, N. A.; Lionel, Sharon; Nair, Sukesh Chandran; Balasubramanian, Poonkuzhali; Mani, Thenmozhi; Abraham, Aby; George, Biju; Mathews, Vikram
- Abstract
Of these, 32 (7.1%) patients had presented with an ICB while another 14 (3.1%) patients developed an ICB during induction therapy. Intracranial bleeding (ICB), either at presentation or during induction, is known to be associated with early deaths in acute promyelocytic leukemia (APL). In patients who were treated with ATO + ATRA ± anthracycline, the 3-year EFS for patients with ICB who were in remission after induction was 100% versus 95.4% ± 2.3% in those who did not have ICB and were in remission after induction.
- Subjects
ACUTE promyelocytic leukemia
- Publication
Blood Cancer Journal, 2023, Vol 13, Issue 1, p1
- ISSN
2044-5385
- Publication type
Article
- DOI
10.1038/s41408-023-00873-z