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- Title
Unusual Clinical Experience in BRAF Exon 15 p.K601E-Mutated Lung Cancer: A Case Report and Brief Review of the Literature.
- Authors
De Felice, Marco; Pisapia, Pasquale; Pepe, Francesco; De Luca, Caterina; Iaccarino, Antonino; Malapelle, Umberto; Troncone, Giancarlo; Ianniello, Giovanni Pietro
- Abstract
Molecular profiling has revolutionized the treatment of metastatic NSCLC. Uncommon mutations have been reported primarily in EGFR and BRAF genes and are frequently associated with atypical clinical presentations. Here, we present a rare case of a patient affected by BRAF exon 15 p.K601E-mutated lung cancer with synchronous peritoneal carcinomatosis. First line treatment with chemo-immunotherapy combinations provided a PFS of 8–9 months, whereas a second line treatment with BRAF and MEK inhibitors elicited a dissociated response. The latter clinical outcome suggests that these inhibitors have only partial activity against this rare mutation.
- Subjects
LUNG cancer; BRAF genes; PERITONEAL cancer; LITERATURE reviews; SYMPTOMS; HYPERTHERMIC intraperitoneal chemotherapy
- Publication
Applied Sciences (2076-3417), 2022, Vol 12, Issue 15, p7552
- ISSN
2076-3417
- Publication type
Case Study
- DOI
10.3390/app12157552