We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Suppressive Activity of Water Mimosa Extract on Human Gastric Cancer Cells.
- Authors
Nguyen, Thanh Quang; Nguyen, Hoang Nhat Minh; Ngo, Dai-Hung; Phan, Phuoc-Hien; Vo, Thanh Sang
- Abstract
Epidemiological studies have evidenced that natural dietary products can prevent or manage gastric cancer. Neptunia oleracea, an aquatic vegetable and edible plant, has been reported to have anti-cancer properties. In this study, N. oleracea extract's suppression of gastric cancer cells was investigated on an in vitro experimental model. We found that ethyl acetate (EtOAc) extract inhibited cell proliferation at IC50 value of 172 µg/mL. Moreover, the treatment of EtOAc extract at a concentration of 50 µg/mL for 24 h caused suppression of cancer cell migration. Notably, a real-time PCR assay revealed that EtOAc extract induced the process of apoptosis via upregulating the mRNA expression level of caspase-8, Bax, caspase-9, and caspase-3 in cancer cells. In conclusion, N. oleracea had potential anti-cancer activity against gastric cancer cells, suggesting its role in the prevention and management of gastric cancer.
- Subjects
STOMACH cancer; CANCER cells; APOPTOSIS; CANCER cell migration; MIMOSA; INHIBITION of cellular proliferation
- Publication
Applied Sciences (2076-3417), 2022, Vol 12, Issue 13, pN.PAG
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app12136817