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- Title
Repression of induction by u.v. of λ phage by exrA mutations in Escherichia coli.
- Authors
Donch, John; Greenberg, Joseph; Green, Michael H. L.
- Abstract
The effect of ultraviolet radiation (u.v.) on λ lysogens of exrA strains of Escherichia coli was studied. exrA strains could be lysogenized with, as well as support the vegetative reproduction of, λ. However, though spontaneous induction of λ occurred in exrA(λ) strain at 10% the frequency of exrA+(λ) strain, exrA(λ) strains were not induced by u.v. Because λ was not induced in exrA(λ) strains, lysogens of these strains were no more sensitive to u.v. than were non-lysogens.The heat-inducible mutant λhcI857 could be induced in exrA strains at elevated temperatures. Furthermore, u.v. irradiation of exrA (λhcI857) strain did not prevent the heat induction of this λ mutant. The exrA mutation appeared to interfere only with the inactivation of λ repressor by u.v.Among the exrA strains studied was strain Bs1(exr A uvrB). Whereas the λ lysogen of strain Bsl could not be induced by u.v. and was no more sensitive to u.v. than its non-lysogen, the exrA+uvrB(λ) derivative of strain Bsl could be induced by u.v. and was more sensitive to u.v. than its non-lysogen.
- Publication
Genetics Research, 1970, Vol 15, Issue 1, p87
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S0016672300001397