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- Title
Involvement of macrophage migration inhibitory factor in cancer and novel therapeutic targets.
- Authors
KINDT, NADÈGE; JOURNE, FABRICE; LAURENT, GUY; SAUSSEZ, SVEN
- Abstract
Macrophage migration inhibitory factor (MIF) was originally identified in 1966 by Bloom and Bennett as a pro-inflammatory cytokine involved in the inhibition of macrophage motility. Since then, studies have investigated the functional contribution of this pro-inflammatory cytokine in several immune diseases, including rheumatoid arthritis and lupus erythematous. Recently, MIF has been reported to be involved in a variety of neoplastic diseases. The present review discusses previous cancer research studies that have investigated the involvement of MIF in carcinogenesis, disease prognosis, tumor cell proliferation and invasion, and tumor-induced angiogenesis. Finally, potential therapeutic approaches based on the use of MIF antagonists and neutralizing antibodies are examined. The review concludes that MIF could be a good prognostic biomarker in several types of cancer, but also that the inhibition of MIF could represent a novel therapy against cancer.
- Subjects
MACROPHAGE migration inhibitory factor; CANCER; CYTOKINES; IMMUNOLOGIC diseases; RHEUMATOID arthritis; CELL proliferation
- Publication
Oncology Letters, 2016, Vol 12, Issue 4, p2247
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2016.4929