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- Title
Cardiac troponin T in extracellular vesicles as a novel biomarker in human cardiovascular disease.
- Authors
Lennon, Kathleen M.; Saftics, Andras; Abuelreich, Sarah; Sahu, Parul; Lehmann, H. Immo; Maddox, Adam L.; Bagabas, Reem; Januzzi, James L.; Van Keuren‐Jensen, Kendall; Shah, Ravi; Das, Saumya; Jovanovic‐Talisman, Tijana
- Abstract
Dear Editor, Soluble cardiac troponin T (cTnT), an indicator of myocardial injury and stress, is used in decision management for patients with cardiovascular disease (CVD). Compared to subjects with negative clinical hs-cTnT content, subjects with positive clinical hs-cTnT had EVs with significantly lower value of cTnT per EV and smaller size. QSMLM data captures how cTnT-positive EVs differed among patients with different causes and severity of cardiac injury, providing complementary information to clinical hs-cTnT to more comprehensively describe the cardiac secretome. Overall, ~14% of EVs contained cTnT; on average, these EVs had a diameter of 118 nm with two detected molecules of cTnT per EV (Figure S4D,E).
- Subjects
EXTRACELLULAR vesicles; MICROFILAMENT proteins; CARDIOVASCULAR diseases; TROPONIN; NEPRILYSIN; PLURIPOTENT stem cells; BIOMARKERS; MYOCARDIAL injury
- Publication
Clinical & Translational Medicine, 2022, Vol 12, Issue 8, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.979