We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Serum Metabolomic Profiling of Piglets Infected with Virulent Classical Swine Fever Virus.
- Authors
Wenjie Gong; Junjie Jia; Bikai Zhang; Shijiang Mi; Li Zhang; Xiaoming Xie; Huancheng Guo; Jishu Shi; Changchun Tu
- Abstract
Classical swine fever (CSF) is a highly contagious swine infectious disease and causes significant economic losses for the pig industry worldwide. The objective of this study was to determine whether small molecule metabolites contribute to the pathogenesis of CSF. Birefly, serum metabolomics of CSFV Shimen strain-infected piglets were analyzed by ultraperformance liquid chromatography/electrospray ionization time-of-flightmass spectrometry (UPLC/ESI-Q-TOF/MS) in combination withmultivariate statistical analysis. In CSFV-infected piglets at days 3 and 7 post-infection changes were found in metabolites associated with several key metabolic pathways, including tryptophan catabolism and the kynurenine pathway, phenylalanine metabolism, fatty acid and lipid metabolism, the tricarboxylic acid and urea cycles, branched-chain amino acid metabolism, and nucleotide metabolism. Several pathways involved in energy metabolismincluding fatty acid biosynthesis and b-oxidation, branched-chain amino acid metabolism, and the tricarboxylic acid cycle were significantly inhibited. Changes were also observed in several metabolites exclusively associated with gut microbiota. The metabolomic profiles indicate that CSFV-host gut microbiome interactions play a role in the development of CSF.
- Subjects
CLASSICAL swine fever; SWINE diseases; PIGLETS; METABOLISM in viruses
- Publication
Frontiers in Microbiology, 2017, Vol 8, p1
- ISSN
1664-302X
- Publication type
Article
- DOI
10.3389/fmicb.2017.00731