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- Title
Determination of Zn 2+ in Solid Pharmaceutical Dosage Forms by Means of Spectrophotometry in Micellar Media: Method Validation.
- Authors
Rus, Luca Liviu; Juncan, Anca Maria; Crăciun, Veronica Isabela; Frum, Adina; Hegheș, Simona-Codruța; Butuca, Anca; Dobrea, Carmen Maximiliana; Chis, Adriana Aurelia; Muntean, Andrei Catalin; Vonica-Ţincu, Andreea Loredana; Morgovan, Claudiu
- Abstract
In this study, a spectrophotometric method for the quantitative determination of zinc in a dietary supplement was validated. Zinc forms a ternary complex with Xylenol Orange and cetylpyridinium chloride in acetate buffer at pH = 5.5. The complex exhibits an absorption maximum at 560 nm. Linearity (range was 0.5–1.5 µg/mL, and correlation coefficient of the calibration curve was 0.9998), precision (repeatability variation coefficient and reproducibility variation coefficient were 1.57% and 1.77%, respectively), and accuracy (confidence interval of the mean recovery was 98.29–100.55%) of this method fulfil current pharmacopeial requests. Results obtained by spectrophotometric method were statistically compared with ones obtained by atomic absorption spectrometry and good agreement was found. The method can be applied routinely for quality control of solid pharmaceutical dosage forms containing zinc.
- Subjects
ORANGE SA; DOSAGE forms of drugs; SOLID dosage forms; ZINC supplements; MICELLAR liquid chromatography; TERNARY forms; CETYLPYRIDINIUM chloride; SPECTROPHOTOMETRY
- Publication
Applied Sciences (2076-3417), 2022, Vol 12, Issue 9, pN.PAG
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app12094476