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- Title
[sup 31] P magnetic resonance spectroscopy in the frontal lobe of major depressed patients.
- Authors
Volz, H.-P.; Rzanny, Reinhard; Riehemann, Stefan; May, Susanne; Hegewald, Helmut; Preussler, Birgitt; Hübner, Gabriele; Kaiser, Werner Alois; Sauer, Heinrich
- Abstract
Abstract Most research with [sup 31]P-magnetic resonance spectroscopy ([sup 31]P-MRS) in affective disorders has been done in the field of bipolar disturbances. Reduced frontal and temporal lobe phosphomonoester (PME) concentrations were measured in the euthymic state, whereas increased values were found in the depressed state. In bipolar-II patients reduced phosphocreatine (PCr) concentrations were reported in the euthymic, depressed, and manic state. The aim of the present study was to explore whether PME and PCr were also altered in the frontal lobe of major depressed, unipolar patients. Therefore, we used [sup 31]P-MRS to investigate the relative phospholipid and high-energy phosphate concentrations in the frontal lobe of 14 unipolar patients, mostly medicated, and 8 age-matched controls. We found increased PME and decreased ATP values. Other [sup 31]P-MRS parameters were not different in both groups. Phosphomonoester percentages correlated negatively with the degree of depression. Thus, the main alterations found in bipolar depressed patients could also be demonstrated in unipolar depressed patients. The results are discussed with regard to disturbed phospholipid and intracellular high-energy phosphate metabolism in depressed patients.
- Subjects
MAGNETIC resonance; SPECTRUM analysis; BIPOLAR disorder; TEMPORAL lobe
- Publication
European Archives of Psychiatry & Clinical Neuroscience, 1998, Vol 248, Issue 6, p289
- ISSN
0940-1334
- Publication type
Article
- DOI
10.1007/s004060050052