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- Title
Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases.
- Authors
Kucuk, Irfan; Yazgan, Yusuf; Yildirim, Idris; Simsek, Tugba Akbaş; Güney, Başak Cakir; Salmanoglu, Musa; Kaplan, Mustafa
- Abstract
Objective: Annexin A1(AnxA1) is an anti-inflammatory mediator. In the current study,we aimed to evaluate whether or not serum Annexin A1 levels of inflammatory boweldiseases (IBDs) patients relate to the clinical and laboratory traits of IBDs. Materials and Methods: This case-control study included 67 ulcerative colitis (UC) patients, 53 Crohn's disease (CD) patients and 60 healthy controls. The Mayo Clinical scoring system (MCS) was used for UC and the histological activity index (HAI) was determined by Truelove and Richards method. The Crohn's disease activity index (CDAI) was used for CD patients. Montreal classification was used for the localization of IBDs. Results: The mean serum AnxA1 concentrations were not statistically significant in UC, CD and the control groups (26.36±17.30 ng/ml vs 22.98±12.74 vs 24.45±12.18 ng/ml respectively, p=0.404). The MCS, HAI of UC patients negatively correlated with the serum AnxA1 values (rho=-0.616, p<0.001 vs rho=-0.778, p<0.001 respectively). UC patients with limited disease had higher values than those with extensive disease (19.5 (IQR:14.5-47.8) ng/ml vs.13.4 (IQR:10.8-18.4) ng/ml respectively, p=0.002). In CD patients, CDAI values negatively correlated to the serum AnxA1 values (rho=-0.770, p<0.001). Conclusions: Serum AnxA1 values might be an auxiliary biomarker for the disease activity in patients with IBDs.
- Subjects
INFLAMMATORY bowel disease diagnosis; INFLAMMATORY bowel disease treatment; REFERENCE values; ANTI-inflammatory agents; INFLAMMATORY mediators; CROHN'S disease; DATA analysis; CALCIUM-binding proteins; KRUSKAL-Wallis Test; ULCERATIVE colitis; DESCRIPTIVE statistics; MANN Whitney U Test; CHI-squared test; INFLAMMATORY bowel diseases; CASE-control method; STATISTICS; BIOMARKERS; SENSITIVITY &; specificity (Statistics)
- Publication
Konuralp Medical Journal / Konuralp Tip Dergisi, 2024, Vol 16, Issue 1, p11
- ISSN
1309-3878
- Publication type
Article
- DOI
10.18521/ktd.1373002