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- Title
Thiol-Disulphide Homoeostasis in COVID-19: Evaluation of its Relationship with Complete Blood Count Parameters.
- Authors
Sekeroglu, Mehmet Ramazan; Cokluk, Erdem; Yaylaci, Selcuk; Erdem, Ali Fuat; Tuncer, Fatima Betul; Dheir, Hamad; Guclu, Ertugrul; Ogutlu, Aziz; Cekic, Deniz; Aydin, Abdülkadir; Cinemre, Fatma Behice
- Abstract
Objective: In this study, we aimed to evaluate the relationship between thiol-disulfide homoeostasis and hemogram parameters in COVID-19 patients. Methods: Total thiol(TT), Native thiol(NT), dynamic disulfide status(DDS), DDS/NT, DDS/TT, NT/TT ratio and CBC parameters were analyzed in 68 patients with positive COVID-19 and 31 healthy individuals. Results: TT, NT, DD, hemoglobin and hematocrit levels were higher in the control group than in patient groups. TT, NT, DD and lymphocyte levels of COVID-19 patients treated in medical floor were higher than those treated in intensive care unit; WBC, neutrophil and NLR were low(P<0.05).PLR was higher in intensive care patients compared with the control group(P<0.05).COVID-19 patients who did not need mechanical ventilation were retrospectively evaluated according to their mortality. TT, NT, DDS and lymphocyte levels were higher; WBC, Neutrophil, PLR and NLR were lower(P<0.05) in survivors. The diagnostic performance of TT, NT and DDS levels to define requirement of intensive care treatment in COVID-19 patients were evaluated by using Receiver Operating Characteristic (ROC) curve analysis. By using ROC analysis, the optimum cut-off points for of TT, NT and DDS levels showed high sensitivity and specificity for requirement of intensive care treatment(P<0.05). Conclusions: According to our results, it has been observed that the thiol-disulfide balance is disrupted In COVID-19 patients. It may be beneficial to monitor the thiol-disulfide balance in the follow-up and treatment of the patients.
- Subjects
HOMEOSTASIS; INTENSIVE care units; COVID-19; HEMOGLOBINS; HEMATOCRIT; LEUCOCYTES; RETROSPECTIVE studies; COMPARATIVE studies; NEUTROPHILS; BLOOD cell count; RECEIVER operating characteristic curves; SENSITIVITY &; specificity (Statistics)
- Publication
Konuralp Medical Journal / Konuralp Tip Dergisi, 2021, Vol 13, p460
- ISSN
1309-3878
- Publication type
Article
- DOI
10.18521/ktd.917364