We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia.
- Authors
Aalbers, A M; Calado, R T; Young, N S; Zwaan, C M; Wu, C; Kajigaya, S; Coenen, E A; Baruchel, A; Geleijns, K; de Haas, V; Kaspers, G J L; Kuijpers, T W; Reinhardt, D; Trka, J; Zimmermann, M; Pieters, R; van der Velden, V H J; van den Heuvel-Eibrink, M M
- Abstract
The article presents a research study which examines the frequency of mutations in telomerase RNA component (TERC) and telomerase reverse transcriptase (TERT) for children with acute myeloid leukemia (AML). Findings reveal that no mutations were observed in TERC, while three non-synonymous variants were found in TERT. It concludes that the variants in TERT and TERC were not likely to be a risk factor for AML in pediatric patients.
- Subjects
TELOMERASE reverse transcriptase; RNA polymerases; HUMAN genetic variation; GENETIC mutation; ACUTE myeloid leukemia in children; JUVENILE diseases; DISEASE risk factors
- Publication
Leukemia (08876924), 2013, Vol 27, Issue 8, p1786
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/leu.2013.57