We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
HLA-DR alleles associated with skin warts induced by human papillomavirus infection.
- Authors
García-Corona, Cristina; Vega-Memije, Elisa; Barquera, Rodrigo; Granados, Julio
- Abstract
Background The skin wart is a benign proliferation of the skin and mucous, secondary to human papillomavirus (HPV) infection. Objectives The objective of this study is to determine gene frequencies of HLA-DR alleles in Mexican patients with skin warts and compare them with those present in ethnically matched healthy subjects. Methods Fifty-two patients with clinically and histologically confirmed skin warts from the Dermatology Outpatient Clinic, with results of high-resolution DNA typing for HLA-DR polymorphism. Results HLA-DR3 and DR9 were increased (P = 0.0029, OR: 2.5, 95% CI: 1.3-4.7 and P = 0.0062, OR: 5.4, 95% CI: 1.4-19.5, respectively), and HLA-DR6 allele was found decreased (P = 0.0002). Limitations The major histocompatibility complex contribution in the infection and elimination of the virus is not clear and perhaps also contributes to a series of events not well established yet. Conclusions This study follows the preponderant role of class II genes in the susceptibility or resistance to the development of skin warts caused by HPV infection.
- Subjects
WARTS; SKIN infections; PAPILLOMAVIRUS diseases; MEXICANS; PATHOLOGICAL physiology; EPITHELIUM; THERAPEUTICS; DISEASES
- Publication
International Journal of Dermatology, 2010, Vol 49, Issue 12, p1376
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/j.1365-4632.2010.04599.x