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- Title
Effects of colchicine on the induction of ornithine decarboxylase and its gene expression by the phorbol ester tumor promoter.
- Authors
Kono, T.; Taniguchi, S.; Mizuno, N.; Fukuda, M.; Maekawa, N.; Hisa, T.; Ishii, M.; Otani, S.; Hamada, T.
- Abstract
The activity and gene expression of ornithine decarboxylase (ODC, an indicator of tumour promotion) were induced by the phorbol ester tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), in mouse skin. In the present study, the effect of colchicine, a microtubule-disrupting agent, on ODC activity and its gene expression were investigated. On administration of colchicine (100 µg) intraperitoneally 1.5 h before TPA treatment, ODC activity and ODC mRNA levels stimulated by TPA were suppressed to about 52 and 64%, respectively. These results suggest the involvement of a microtubule or colchicine-sensitive substrate in the signal transduction system for gene expression.
- Subjects
ORNITHINE decarboxylase; COLCHICINE; GENE expression; PHORBOL esters; COCARCINOGENS
- Publication
Clinical & Experimental Dermatology, 1993, Vol 18, Issue 4, p314
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/j.1365-2230.1993.tb02205.x