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- Title
Impact of Prenatal Care on Newborn Complications for Infants with Cleft Lip with or Without Cleft Palate.
- Authors
Loomis-Goltl, Evy; Briley, Patrick; Kotlarek, Katelyn J.
- Abstract
Objective: To determine the association between prenatal care and cleft lip with or without cleft palate (CL ± P) and examine differences in newborn complications among infants diagnosed with CL ± P as a function of prenatal care Design: Population-based retrospective cohort study Setting: 2018 United States National Vital Statistics System—Natality component (NVSS-N) was used to examine nationwide birth certificate data Participants: 3,414,338 infants from the 2018 National Vital Statistics System, of which 1,699 had CL ± P Main Outcome Measure: Diagnosis of CL ± P and presence of newborn complications as a function of prenatal care Results: Significant differences were found among various infant- and mother-specific variables when baseline comparisons were made between infants with and without CL ± P. After controlling for baseline differences, results indicated decreased odds of a diagnosis of CL ± P in cases where overall adequate prenatal care was obtained (OR =.841; 95% CI.757,.934), including prenatal care beginning in the 1st trimester (OR =.839; 95% CI.750,.939) and an adequate number of prenatal visits received (OR =.864; 95% CI.764,.976). Of infants with CL ± P, reduced odds of the infant admitted to the neonatal intensive care unit (OR =.777; 95% CI.613,.985) or transferred (OR =.601; 95% CI.407,.888) were apparent when adequate prenatal care was received. Conclusion: Results suggest adequate prenatal care not only reduces the likelihood of CL ± P in infants but may also decrease the severity of negative outcomes in infants diagnosed with CL ± P. These findings emphasize necessity for adequate prenatal care.
- Subjects
UNITED States; CLEFT lip -- Risk factors; RISK assessment; STATISTICAL correlation; RESEARCH funding; NEONATAL intensive care units; RETROSPECTIVE studies; REPORTING of diseases; NEONATAL intensive care; PRENATAL care; LONGITUDINAL method; ODDS ratio; HOSPITAL care of newborn infants; RESEARCH; MEDICAL appointments; CLEFT lip; PREGNANCY complications; COMPARATIVE studies; CONFIDENCE intervals; FIRST trimester of pregnancy; CLEFT palate; DISEASE risk factors
- Publication
Cleft Palate Craniofacial Journal, 2024, Vol 61, Issue 6, p1041
- ISSN
1055-6656
- Publication type
Article
- DOI
10.1177/10556656231153453