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- Title
Sertoli-Leydig Cell Tumour and DICER1 Mutation: A Case Report and Review of the Literature.
- Authors
Wormald, B.; Elorbany, S.; Hanson, H.; Williams, J. W.; Heenan, S.; Barton, D. P. J.
- Abstract
Sertoli-Leydig cell tumours of the ovary (SLCT) are rare tumours predominantly caused by mutations in the DICER1 gene. We present a patient with a unilateral SLCT who had an underlying germline DICER1 gene mutation. We discuss the underlying pathology, risks, and screening opportunities available to those with a mutation in this gene as SLCT is only one of a multitude of other tumours encompassing DICER1 syndrome. The condition is inherited in an autosomal dominant fashion. As such, genetic counselling is a key component of the management of women with SLCT.
- Subjects
LEYDIG cell tumors; SERTOLI cells; GENETIC mutation; MEDICAL screening; TUMOR treatment; MEDICAL literature reviews
- Publication
Case Reports in Obstetrics & Gynecology, 2018, p1
- ISSN
2090-6684
- Publication type
Article
- DOI
10.1155/2018/7927362