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- Title
A Statistical Multiprobe Model for Analyzing cis and trans Genes in Genetical Genomics Experiments With Short-Oligonucleotide Arrays.
- Authors
Alberts, Rudi; Terpstra, Peter; Bystrykh, Leonid V.; de Haan, Gerald; Jansen, Ritsert C.
- Abstract
Short-oligonucleotide arrays typically contain multiple probes per gene. In genetical genomics applications a statistical model for the individual probe signals can help in separating "true" differential mRNA expression from "ghost" effects caused by polymorphisms, misdesigned probes, and batch effects. It can also help in detecting alternative splicing, start, or termination.
- Subjects
OLIGONUCLEOTIDES; NUCLEIC acid probes; GENES; MESSENGER RNA; GENOMICS; GENE expression
- Publication
Genetics, 2005, Vol 171, Issue 3, p1437
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1534/genetics.105.045930