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- Title
Inhibitory Effects of Nitrogenous Metabolites from a Marine-Derived Streptomyces bacillaris on Isocitrate Lyase of Candida albicans.
- Authors
Chung, Beomkoo; Hwang, Ji-Yeon; Park, Sung Chul; Kwon, Oh-Seok; Cho, Eunji; Lee, Jayho; Lee, Hyi-Seung; Oh, Dong-Chan; Shin, Jongheon; Oh, Ki-Bong
- Abstract
Two nitrogenous metabolites, bacillimide (1) and bacillapyrrole (2), were isolated from the culture broth of the marine-derived actinomycete Streptomyces bacillaris. Based on the results of combined spectroscopic and chemical analyses, the structure of bacillimide (1) was determined to be a new cyclopenta[c]pyrrole-1,3-dione bearing a methylsulfide group, while the previously reported bacillapyrrole (2) was fully characterized for the first time as a pyrrole-carboxamide bearing an alkyl sulfoxide side chain. Bacillimide (1) and bacillapyrrole (2) exerted moderate (IC50 = 44.24 μM) and weak (IC50 = 190.45 μM) inhibitory effects on Candida albicans isocitrate lyase, respectively. Based on the growth phenotype using icl-deletion mutants and icl expression analyses, we determined that bacillimide (1) inhibits the transcriptional level of icl in C. albicans under C2-carbon-utilizing conditions.
- Subjects
STREPTOMYCES; CANDIDA albicans; METABOLITES; ANALYTICAL chemistry
- Publication
Marine Drugs, 2022, Vol 20, Issue 2, pN.PAG
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md20020138