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- Title
Diterpenoids from the Brown Alga Rugulopteryx okamurae and Their Anti-Inflammatory Activity.
- Authors
Cuevas, Belén; Arroba, Ana I.; de los Reyes, Carolina; Gómez-Jaramillo, Laura; González-Montelongo, M. Carmen; Zubía, Eva
- Abstract
Brown algae of the Family Dictyotaceae produce an array of structurally diverse terpenoids, whose biomedical potential in the anti-inflammatory area has been scarcely explored. Herein, the chemical study of the alga Rugulopteryx okamurae has led to the isolation of ten new diterpenoids: rugukadiol A (1), rugukamurals A–C (2–4), and ruguloptones A–F (6–10). The structures of the new compounds were established by spectroscopic means. Compound 1 exhibits an unprecedented diterpenoid skeleton featuring a bridged tricyclic undecane system. Compounds 2–10 belong to the secospatane class of diterpenoids and differ by the oxygenated functions that they contain. In anti-inflammatory assays, the new diterpenoid 1 and the secospatanes 5 and 10 significantly inhibited the production of the inflammatory mediator NO in LPS-stimulated microglial cells Bv.2 and macrophage cells RAW 264.7. Moreover, compounds 1 and 5 were found to strongly inhibit the expression of Nos2 and the pro-inflammatory cytokine Il1b in both immune cell lines.
- Subjects
DITERPENES; ANTI-inflammatory agents; INFLAMMATORY mediators; TERPENES; CELL lines; BROWN algae
- Publication
Marine Drugs, 2021, Vol 19, Issue 12, p677
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md19120677