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- Title
Antibacterial Bicyclic Fatty Acids from a Korean Colonial Tunicate Didemnum sp.
- Authors
Kim, Hiyoung; Lee, Tae Gu; Yang, Inho; Wang, Weihong; Chin, Jungwook; Lee, Jusung; Rho, Boon Jo; Choi, Hyukjae; Nam, Sang-Jip; Hahn, Dongyup; Kang, Heonjoong
- Abstract
Five new bicyclic carboxylic acids were obtained by antibacterial activity-guided isolation from a Korean colonial tunicate Didemnum sp. Their structures were elucidated by the interpretation of NMR, MS and CD spectroscopic data. They all belong to the class of aplidic acids. Three of them were amide derivatives (1–3), and the other two were dicarboxylic derivatives (4 and 5). The absolute configurations were determined by a bisignate pattern of CD spectroscopy, which revealed that the absolute configurations of amides were opposite to those of dicarboxylates at every stereogenic centers. Compound 2 exhibited the most potent antibacterial activity (MIC, 2 μg/mL).
- Subjects
COLONIAL animals (Marine invertebrates); FATTY acids; ANTIBACTERIAL agents; AMIDES
- Publication
Marine Drugs, 2021, Vol 19, Issue 9, p521
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md19090521