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- Title
Diagnostika a prognostické faktory lymfomu z buněk pláště.
- Authors
A., Obr; M., Mikešová; M., Jarošová; V., Procházka; B., Tessoulin; T., Papajík
- Abstract
Mantle cell lymphoma (MCL) was first described as a diagnostic entity in the R.E.A.L. (Revised European-American Classification of Lymphoid Neoplasms) classification in 1994. MCL is a malignant disease arising from B-lymphocytes. It is characterised by overexpression of cyclin D1 and by chromosomal translocation t(11;14)(q13;q32). The origin of tumour cells is inner mantle zone of lymphatic follicles. MCL is substantially heterogeneous disease by its morphologic and biologic characteristics. Clinical course can be really slow in indolent form of the disease or conversely very quick in aggressive form of MCL. Strict diagnostics and careful evaluation of prognostic markers are important in patients with this kind of lymphoma because of its biologic and clinical heterogeneity.
- Publication
Transfusiology & Haematology Today / Transfuze a Hematologie Dnes, 2016, Vol 22, Issue 3, p190
- ISSN
1213-5763
- Publication type
Article