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- Title
Svalbamides A and B, Pyrrolidinone-Bearing Lipodipeptides from Arctic Paenibacillus sp.
- Authors
Du, Young Eun; Bae, Eun Seo; Lim, Yeonjung; Cho, Jang-Cheon; Nam, Sang-Jip; Shin, Jongheon; Lee, Sang Kook; Nam, Seung-Il; Oh, Dong-Chan
- Abstract
Two new secondary metabolites, svalbamides A (1) and B (2), were isolated from a culture extract of Paenibacillus sp. SVB7 that was isolated from surface sediment from a core (HH17-1085) taken in the Svalbard archipelago in the Arctic Ocean. The combinational analysis of HR-MS and NMR spectroscopic data revealed the structures of 1 and 2 as being lipopeptides bearing 3-amino-2-pyrrolidinone, d-valine, and 3-hydroxy-8-methyldecanoic acid. The absolute configurations of the amino acid residues in svalbamides A and B were determined using the advanced Marfey's method, in which the hydrolysates of 1 and 2 were derivatized with l- and d- forms of 1-fluoro-2,4-dinitrophenyl-5-alanine amide (FDAA). The absolute configurations of 1 and 2 were completely assigned by deducing the stereochemistry of 3-hydroxy-8-methyldecanoic acid based on DP4 calculations. Svalbamides A and B induced quinone reductase activity in Hepa1c1c7 murine hepatoma cells, indicating that they represent chemotypes with a potential for functioning as chemopreventive agents.
- Subjects
PAENIBACILLUS; AMINO acid residues; QUINONE; METABOLITES; STEREOCHEMISTRY; DATA structures
- Publication
Marine Drugs, 2021, Vol 19, Issue 4, p229
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md19040229