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- Title
A Double-blind Investigation of the Potential Systemic Absorption of Isotretinoin, when Combined with Chemical Sunscreens, Following Topical Application to Patients with Widespread Acne of the Face and Trunk.
- Authors
Cunliffe, William J.; Glass, Daniel; Goode, Karen; Stables, Graham I.; Boorman, Graham C.
- Abstract
This study assessed the systemic absorption of isotretinoin and its metabolites, during a 4-week application of a cream containing 0.1% isotretinoin and chemical sunscreens, compared with a 4% benzoyl peroxide cream, in patients with acne on the face and trunk. Blood was drawn at weeks 0, 1, 2, 3 and 4 and at 96 h post-treatment. Plasma levels of isotretinoin (13-cisretinoic acid) and tretinoin (all-trans-retinoic acid) were quantified by liquid chromatography with tandem mass spectrometry and the presence of their combined 4-oxo metabolites were monitored from the peak area ratios observed. The isotretinoin group showed no statistically or clinically significant increases in plasma retinoid levels and mean levels did not exceed ± 2 SD of the mean pre-treatment values, indicating that endogenous levels were not being exceeded. No significant differences were detected between the isotretinoin group and the 4% benzoyl peroxide group. These findings indicated that retinoid absorption from a cream containing 0.1% isotretinoin and chemical sunscreens was clinically insignificant, when applied to patients with widespread acne.
- Subjects
ACNE; ISOTRETINOIN; DRUG therapy; PHARMACOKINETICS
- Publication
Acta Dermato-Venereologica, 2001, Vol 81, Issue 1, p14
- ISSN
0001-5555
- Publication type
Article
- DOI
10.1080/000155501750208119