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- Title
The Effect of the Molecular Architecture on the Antioxidant Properties of Chitosan Gallate.
- Authors
Chunhua Wu; Liping Wang; Zhongxiang Fang; Yaqin Hu; Shiguo Chen; Tatsuya Sugawara; Xingqian Ye
- Abstract
To elucidate the structure-antioxidant activity relationships of chitosan gallate (CG), a series of CG derivatives with different degrees of substitution (DS's) and molecular weights (MWs) were synthesized from chitosan (CS) and gallic acid (GA) via a free radical graft reaction. A higher MW led to a lower DS of CG. The structures of CG were characterized by FT-IR and ¹H NMR, and results showed that GA was mainly conjugated to the C-2 and C-6 positions of the CS chain. The antioxidant activity (the DPPH radical scavenging activity and reducing power) were enhanced with an increased DS and a decreased MW of CG. A correlation between antioxidant activities and the DS and MW of CG was also established. In addition, a suitable concentration (0~250 µg/mL) of CG with different MWs (32.78~489.32 kDa) and DS's (0~92.89 mg⋅ GAE/g CG) has no cytotoxicity. These results should provide a guideline to the application of CG derivatives in food or pharmacology industries.
- Subjects
ANTIOXIDANTS; GALLATES; CHITOSAN; MOLECULAR structure; FREE radicals
- Publication
Marine Drugs, 2016, Vol 14, Issue 5, p95
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md14050095