We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4.
- Authors
Bishop, Tammie; Ratcliffe, Peter J.
- Abstract
The mechanistic basis of the marked oxygen sensitivity of glomus cells in the carotid body has long puzzled physiologists. In this issue of Science Signaling, Moreno-Domínguez et al. show the critical importance of high levels of hypoxia-inducible factor, HIF2α/EPAS1, and the nuclear-encoded mitochondrial cytochrome c oxidase subunit, COX4I2, in glomus cell sensitivity to hypoxia.
- Subjects
CAROTID body; CYTOCHROME oxidase; SOMATIC sensation; HYPOXIA-inducible factors; OXYGEN
- Publication
Science Signaling, 2020, Vol 13, Issue 615, p1
- ISSN
1945-0877
- Publication type
Article
- DOI
10.1126/scisignal.aba1302