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- Title
Cellular kinetics and lectin distribution in hamster buccal carcinomas.
- Authors
Nlshlkawa, Tetsunarl; Wada, Seiji; Wato, Masahiro; Tsutsui, Jun; Nishimura, Vasunori; Matsuoka, Kayo; Okano, Hakuro; Tanaka, Akio
- Abstract
As part of an evaluation of the progression to malignancy, the cellular kinetics of DMBA-induced tumors in the buccal mucosa of hamsters were examined using 5-bromodeoxyuridine (BrdU), peanut agglutinin (PNA), Ulex europaeus agglutinin 1 (UEA-I) and wheat germ agglutinin (WGA). BrdU-positive cells were localized in the basal layer in both normal and hyperplastic epithelium, whereas they were distributed from the basal to the prickle cell layer in squamous cell carcinoma (SCC). The extent of BrdU labeling increased as the tissues progressed towards malignancy. PNA and UEA-I showed binding only in the prickle cell layer of normal and hypcrplastic epithelium, and WGA showed binding mainly in the prickle cell layer. However, in SCC, PNA and UEA-I showed no binding in the prickle cell layer and WGA binding was observed throughout the epithelium. A study of cellular kinetics using BrdU labeling and the lectin binding pattern may bc useful in the evaluation of tissue changes on the way to malignancy.
- Subjects
BROMODEOXYURIDINE; CARCINOGENESIS; LECTINS; HAMSTERS; URIDINE; NUCLEOSIDES; PATHOLOGY
- Publication
Journal of Oral Pathology & Medicine, 1994, Vol 23, Issue 1, p17
- ISSN
0904-2512
- Publication type
Article
- DOI
10.1111/j.1600-0714.1994.tb00248.x