We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.
- Authors
Tae Hyung Won; Chang-Kwon Kim; So-Hyoung Lee; Boon Jo Rho; Sang Kook Lee; Dong-Chan Oh; Ki-Bong Oh; Jongheon Shin
- Abstract
Four new iodobenzene-containing dipeptides (1-4), a related bromotryptophancontaining dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea. The structures of these novel compounds, designated as apliamides A-E (1-5) and apliamine A (6) were determined via combined spectroscopic analyses. The absolute configuration of the amino acid residue in 1 was determined by advanced Marfey's analysis. Several of these compounds exhibited moderate cytotoxicity and significant inhibition against Na+/K+-ATPase (4).
- Subjects
SEA squirts; AMINO acid residues; MARINE metabolites; DIPEPTIDES; IODOBENZENE; CELL-mediated cytotoxicity
- Publication
Marine Drugs, 2015, Vol 13, Issue 6, p3836
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md13063836