We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Phytochemical analysis and Enzyme Inhibition Assay of Aerva javanica for Ulcer.
- Authors
Khan, Abdul Wajid; Jan, Saleem; Parveen, Shaista; Khan, Rahmat Ali; Saeed, Asma; Tanveer, Abdul Jabbar Anwar Ali Shad; Shad, Anwar Ali
- Abstract
Background: Aerva javanica (Burm. f.) Juss. ex Schult. (Amaranthacea) is traditionally used for the treatment of wound healings, cough, diarrhoea, ulcer and hyperglycaemia. The current study was aimed to fractionate and isolate bioactive compounds and ultimately to evaluate their anti-ulcereogenic potential. Results: In order to achieve these aims, the fractionation, purifications and then biological potential determination of the isolated compounds was carried out. For purification purpose, initially extraction of the plant material was done with aqueous MeOH in the order of increasing polarity by using solvent-solvent extraction method. Phytochemical analysis revealed the presence of three compounds, 3-hydroxy-4 methoxybenzaldehyde (1), ursolic acid (2) and (E)-N-(4-hydroxy-3-methoxyphenethyl)-3-(4-hydroxy-3-ethoxyphenyl) acryl amide (3). Inhibition of urease activity of various fractions revealed that ethyl acetate fraction showed significant activity (P <0.05) as compared to other fractions. (E)-N-(4-hydroxy-3-methoxyphenethyl)-3-(4-hydroxy-3-ethoxyphenyl) acryl amide (3) showed marked anti ulcer activity (P <0.05). Conclusion: These results suggested the mild potential of A. javanica against ulcer.
- Subjects
DIARRHEA; AERVA; AMARANTHACEAE; BOTANICAL specimens; BIOACTIVE compounds; INTESTINAL diseases; COMMON cold; AMIDASES
- Publication
Chemistry Central Journal, 2012, Vol 6, Issue 1, p76
- ISSN
1752-153X
- Publication type
Article
- DOI
10.1186/1752-153X-6-76