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- Title
Risk of cancer in patients with insomnia: Nationwide retrospective cohort study (2009–2018).
- Authors
Yoon, Kichul; Shin, Cheol Min; Han, Kyungdo; Jung, Jin Hyung; Jin, Eun Hyo; Lim, Joo Hyun; Kang, Seung Joo; Choi, Yoon Jin; Lee, Dong Ho
- Abstract
Purpose: To investigate the association between insomnia and the risk of various cancers using the Korean National Health Insurance Service database. Materials and methods: Patients who underwent a national health examination in 2009 were followed-up until 2018. Newly-diagnosed cancers were collected one year after the baseline. Insomnia was defined as having a diagnosis of F510 or G470 within one year prior to enrollment. The incidence of various cancers was compared between patients with and without insomnia. Results: In the overall study population (N = 3,982,012), the risk for any type of cancer was not different between controls and insomnia patients (adjusted hazard ratio [aHR]: 0.990). However, it was different by age; insomnia increased the risk of any cancer in younger age groups (20–39y and 40–59y, aHR:1.310 and 1.139, respectively) but it significantly decreased the risk in the 60–79y age group (aHR: 0.939). In cancer type, colorectal cancer risk was lower (aHR: 0.872, P < 0.0001), whereas leukemia risk was higher (aHR: 1.402, P < 0.0001) in patients with insomnia than in those without it, regardless of sex. In men, the risk of stomach cancer was lower (aHR: 0.882, P = 0.0003), and the risks of lung (aHR:1.114, P = 0.0005), kidney (aHR 1.226, P = 0.0107), and prostate (aHR:1.101, P = 0.0028) cancers were higher in insomnia patients than in control patients. In women, insomnia patients compared to control patients showed a lower risk of ovarian cancer (aHR:0.856, P = 0.0344, respectively), while they had a higher risk of oral (aHR:1.616, P = 0.002), thyroid (aHR:1.072, P = 0.0192), and nerve (aHR: 1.251, P = 0.016) cancers. Conclusion: Insomnia is associated with an increased or decreased risk of some cancers, depending on age, cancer type and sex.
- Subjects
DISEASE risk factors; INSOMNIACS; LUNGS; NATIONAL health insurance; COHORT analysis; PROSTATE; STOMACH cancer
- Publication
PLoS ONE, 2023, Vol 17, Issue 4, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0284494