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- Title
Antidiarrhoeal effect of the crude methanol extract of the dried fruit of Adansonia digitata L. (Malvaceae).
- Authors
Mohammed Musa Suleiman; Mohammed Mamman; Hassan, Ibrahim; Garba, Shamsu; Kawu, Mohammed Umaru; Kobo, Patricia Ishaku
- Abstract
Aim: The study was designed to evaluate the antidiarrhoeal property of the methanol extract of the fruit of Adansonia digitata using laboratory animal models. Materials and Methods: The acute oral toxicity (LD 50) of the extract was determined in mice, while the antidiarrhoeal effect of different doses of the extract was evaluated in both mice and rats. The effect of the extract at doses of 300, 700 and 1000 mg/kg were tested against intestinal transit time, magnesium sulphate-induced gastrointestinal motility test and castor oil-induced diarrhoea in mice. Similarly, the extract at the doses mentioned above was evaluated against castor-oil induced enteropoolingin rats. Results: The methanol extract of A. digitata was shown to have no toxic effect in mice at doses up to 5000 mg/kg.At doses of 300 and 700 mg/kg the extract significantly (p<0.01) decrease intestinal transit timein mice. In addition, the extract at doses of 300, 700 and 1000 mg/kg, significantly (p<0.05) lowered diarrhoea induced by magnesium sulphate and castor oil in mice. Similarly, the extract produced a significant (p<0.05) inhibition of enteropooling caused by castor oil in rats. The antidiarrhoeal effectofthe extract was shownto bedose-dependent. Conclusion: These findings revealed the potential of the extract of fruit of A. digitata as an antidiarrhoeal agent. The detailed mechanism of the extract antidiarrhoeal action is yet to be ascertained. However, one or more of the phytoconstituents contained inthe extract couldberesponsible for the observed antidiarrhoeal effect.
- Subjects
ANTIDIARRHEALS; ADANSONIA digitata; METHANOL; THERAPEUTIC use of plant extracts; MAGNESIUM sulfate; GASTROINTESTINAL motility; VETERINARY medicine
- Publication
Veterinary World, 2014, Vol 7, Issue 7, p496
- ISSN
0972-8988
- Publication type
Article
- DOI
10.14202/vetworld.2014.496-500