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- Title
Autoantibodies to Tumor-Associated Antigens in Epithelial Ovarian Carcinoma.
- Authors
Piura, Benjamin; Piura, Ettie
- Abstract
This review will focus on recent knowledge related to circulating autoantibodies (AAbs) to tumor-associated antigens (TAAs) in epithelial ovarian carcinoma. So far, the following TAAs have been identified to elicit circulating AAbs in epithelial ovarian carcinoma: p53, homeobox proteins (HOXA7,HOXB7), heat shock proteins (HSP-27, HSP-90), cathepsin D, cancer-testis antigens (NY-ESO-1/LAGE-1), MUC1, GIPC-1, IL-8, Ep-CAM, and S100A7. Since AAbs to TAAs have been identified in the circulation of patients with early-stage cancer, it has been speculated that the assessment of a panel of AAbs specific for epithelial ovarian carcinoma TAAs might hold great potential as a novel tool for early diagnosis of epithelial ovarian carcinoma.
- Subjects
AUTOANTIBODIES; TUMOR antigens; OVARIAN cancer; EPITHELIAL cells; HOMEOBOX genes; HEAT shock proteins; CANCER patients; DIAGNOSIS of cancer in female reproductive organs; CIRCULATING anticoagulants; DISEASES
- Publication
Journal of Oncology, 2009, p1
- ISSN
1687-8450
- Publication type
Article
- DOI
10.1155/2009/581939