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- Title
Japanese growth prediction model for prepubertal children with growth hormone deficiency.
- Authors
Seino, Yoshiki; Yamashita, Sumie; Morisaki, Yoji; Tanaka, Hiroyuki; Chihara, Kazuo; Tanaka, Toshiaki
- Abstract
Background: Individual responses to growth hormone (GH) treatment are variable, and efficacy should be judged in each individual patient. Objective: The aim of this study was to develop a prediction model for the growth response of GH treatment in Japanese prepubertal children with GH deficiency. Patients and methods: Pediatric patients with GH deficiency were enrolled. Auxological measurements, markers of GH status, and markers of bone metabolism were measured at baseline and at 3 and 6 months after the start of GH treatment. Correlations with height velocity (HV) at 36 months of GH treatment were calculated. Prediction models were evaluated by multiple regression analysis. Results: The model, which combined the parameters of HV at 3 months, insulin-like growth factor-binding protein 3, standard deviation score, and pyridinoline at 3 months, best predicted HV at 36 months. Conclusions: This model can accurately predict the first 3 years of growth response after 3 months of GH replacement therapy in prepubertal Japanese children.
- Publication
Journal of Pediatric Endocrinology & Metabolism, 2012, Vol 25, Issue 9/10, p909
- ISSN
0334-018X
- Publication type
Article
- DOI
10.1515/jpem-2012-0189