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- Title
SSeCKS Promotes Tumor Necrosis Factor-α Autocrine via Activating p38 and JNK Pathways in Schwann Cells.
- Authors
Zhengming Zhou; Tao Tao; Yuhong Ji; Huiguang Yang; Youhua Wang; Chun Cheng; Aiguo Shen; Xiang Lu
- Abstract
Tumor necrosis factor-alpha (TNF-α) derived from activated Schwann cells (SCs) plays a critical role as an inflammatory mediator in the peripheral nervous system disease. TNF-α could act as an autocrine mediator in SC activation. In this study, we found knockdown Src-suppressed protein kinase C substrate (SSeCKS) expression suppressed TNF-α production induced by TNF-α, overexpression of SSeCKS could promoted TNF-α autocrine in SCs. Such effects might be resulted in SSeCKS promoted p38 and JNK activation in SCs treated by TNF-α. Thus present data show that while SCs activation, SSeCKS may plays an important role in the release of inflammatory mediators.
- Subjects
TUMOR necrosis factors; NERVOUS system; AUTOCRINE mechanisms; PROTEIN kinases; NEUROGLIA
- Publication
Cellular & Molecular Neurobiology, 2010, Vol 30, Issue 5, p701
- ISSN
0272-4340
- Publication type
Article
- DOI
10.1007/s10571-009-9494-z