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- Title
An eighteen months' study of the clinical response to metoprolol, a selective beta1-receptor blocking agent, in patients with angina pectoris.
- Authors
Comerford, M. B.; Besterman, E. M.
- Abstract
Following an initial dose response study, metoprolol, a selective beta1-receptor blocking agent, was compared with equipotent dosages of propanolol in a double blind cross-over study, including exercise tolerance tests, on fourteen patients with angina pectoris. Long term therapy with metoprolol then followed until the seventy-second week. Patients performed 8% more total work on metoprolol with 15% more work recorded up to the onset of S-T depression, in comparison with propranolol. In the long term, ther was no significant difference in work performed when the daily dosage of metoprolol was changed from a q.i.d. to a b.d. regime. Metoprolol was shown to be an effective anti-anginal compound with good tolerance and safety, with gradual improvement in underlying myocardial ischaemia during long term treatment.
- Subjects
ADRENERGIC beta blockers; DRUG therapy for angina pectoris; METOPROLOL; PROPRANOLOL; PROPANOLAMINES; CLINICAL trials; COMPARATIVE studies; EXERCISE tests; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RESEARCH; EVALUATION research; RANDOMIZED controlled trials; THERAPEUTICS
- Publication
Postgraduate Medical Journal, 1976, Vol 52, Issue 610, p481
- ISSN
0032-5473
- Publication type
journal article