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- Title
Sensorimotor adaptation of voice fundamental frequency in Parkinson's disease.
- Authors
Abur, Defne; Lester-Smith, Rosemary A.; Daliri, Ayoub; Lupiani, Ashling A.; Guenther, Frank H.; Stepp, Cara E.
- Abstract
Objective: This study examined adaptive responses to auditory perturbation of fundamental frequency (fo) in speakers with Parkinson’s disease (PD) and control speakers. Method: Sixteen speakers with PD and nineteen control speakers produced sustained vowels while they received perturbed auditory feedback (i.e., fo shifted upward or downward). Speakers’ pitch acuity was quantified using a just-noticeable-difference (JND) paradigm. Twelve listeners provided estimates of the speech intelligibility for speakers with PD. Results: Fifteen responses from each speaker group for each shift direction were included in analyses. While control speakers generally showed consistent adaptive responses opposing the perturbation, speakers with PD showed no compensation on average, with individual PD speakers showing highly variable responses. In the PD group, the degree of compensation was not significantly correlated with age, disease progression, pitch acuity, or intelligibility. Conclusions: These findings indicate reduced adaptation to sustained fo perturbation and higher variability in PD compared to control participants. No significant differences were seen in pitch acuity between groups, suggesting that the fo adaptation deficit in PD is not the result of purely perceptual mechanisms. Significance: These results suggest there is an impairment in vocal motor control in PD. Building on these results, contributions can be made to developing targeted voice treatments for PD.
- Subjects
PARKINSON'S disease patients; WORD deafness; AUDITORY acuity; VOICE frequency; INTELLIGIBILITY of speech; DIAGNOSIS
- Publication
PLoS ONE, 2018, Vol 13, Issue 1, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0191839